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Mechanistically, the downregulation of peroxisome proliferator-activated receptor mediates the regulation of fatty acid-binding protein 1 on GPX4 and ACSL4, leading to ferroptosis and promoting the development of IgA nephropathy (273)
Here, Ekihiro Seki & team implicate the fungal sensing adaptor protein CARD9 in maintaining gut barrier integrity under metabolic stress, finding that the loss of fungal sensing exacerbates liver injury in a murine model of MASLD
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Access this article Similar content being viewed by others Data Availability The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request