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However, these trials were done with older GLP-1 drugs

As documented by the FDA, practices such as taking a higher amount of the drug in a single dose, taking doses more frequently, or increasing the amount of the drug more quickly can cause serious gastrointestinal problems, including nausea, vomiting, diarrhea, and abdominal pain

But what happens when we consider combining these two distinct yet complementary approaches

fda.gov

However, the physiological mechanismprolonged gastric retention leading to increased intra-gastric pressureprovides a plausible explanation for why some patients may develop these symptoms

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