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Drugs versus microbiota: how pharmacotherapy affects gut and probiotic bacteria

In Vivo Assessment of Drug Interactions Effect of Sitagliptin on Other Drugs In clinical studies, as described below, sitagliptin did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, warfarin, or oral contraceptives, providing in vivo evidence of a low propensity for causing drug interactions with substrates of CYP3A4, CYP2C8, CYP2C9, and organic cationic transporter (OCT)

These results inform whether you're a candidate for maintenance therapy, dual-compound protocols, or alternative strategies to minimize rebound

If you're considering a timing change, 1 day is a safer experiment

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placebo) can be found in Table 3