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Burns DK, Alexander RC, Welsh-Bohmer KA, Culp M, Chiang C, ONeil J, et al

As MOTS-c activates AMPK and NRF2, it also indirectly suppresses the mTOR (mechanistic target of rapamycin) pathway, the master growth and anabolism regulator that, when chronically overactivated, accelerates the accumulation of senescent cells