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At the same time, the incidence of diabetic nephropathy, although reduced compared to 20 years ago, is stabilized in recent years, and the incidence of end-stage renal disease (due to reduced cardiovascular mortality and increased life expectancy) is increasing [64]

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Both medications require long-term use for sustained benefit, with weight regain common after discontinuation

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One-way analysis of variance (ANOVA) was performed to assess the differences between experimental groups