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An improved process for the preparation of Semaglutide, comprising reacting (3-31) amino acid fragment of Semaglutide having the amino acid sequence Glu-Gly-Thr-Phe- Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu- Val-Arg-Gly-Arg-Gly with PGi-His(PG)-Aib-OH to provide a peptide having amino acid sequence His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly- Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly and optionally converting the obtained compound to Semaglutide, wherein, PG and PGi independently represents protecting groups

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Drug label for [Vyleesi, NDA 210557]

Christen, S

This minimizes waste during the low-dose ramp and maximizes value during the high-consumption maintenance period

those receiving semaglutide for weight reduction should use adequate contraception and discontinue semaglutide if pregnancy occurs