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For researchers and interested readers, monitoring registered clinical trial databases such as ClinicalTrials.gov and peer-reviewed preclinical journals remains the most reliable way to track meaningful new developments

In the CY2026 PFS ( proposed rule, we referred to the description of this proposed approach that CMS previously provided in the CY 2025 proposed rule, namely, that this policy, if finalized, would result in a QP calculation that, by including beneficiaries receiving any covered professional service, more accurately reflect eligible clinicians' actual participation in Advanced APMs, improve transparency and predictability of the determinations, be more operationally efficient than the current policy, and better align the QP determination methodology with the universe of services to which the Quality Payment Program (including MIPS and APMs) applies

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For example, initial parenteral treatment is used when the clinical symptoms are severe [12]