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Stability depends on consistent temperature any excursion above 8C shortens the viable storage window, and freezing reconstituted peptides causes ice crystal formation that mechanically damages the protein structure

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125 MonteroJ.MariM.ColellA.MoralesA.BasanezG.Garcia-RuizC.et al (2010)

The American Diabetes Association recommends checking HbA1c at least every three months until glycemic targets are achieved, then at least twice yearly thereafter

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TPO-Ab positivity, often used as a marker of thyroid autoimmunity, has been associated with elevated pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-) (19, 20), which can have systemic effects beyond the thyroid gland (21, 22)