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Some promising approaches include the following: - Garlic-derived allicin: reduces TMAO in murine models (C57BL/6 mice), suggesting anti-atherosclerotic potential ( - TMA lyase inhibitors: synthetic compounds (e.g., fluoromethylcholine, FMC) that irreversibly inhibit CutC/D (Roberts et al., 2018)
Gillingham M, Van Calcar S, Ney D, Wolff J, Harding C: Dietary management of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD)
American Journal of Lifestyle Medicine, 12(6), 499512
2,3 The majority of patients report an infection associated with onset
It is not recommended for chronic use beyond 12 weeks without clinical reassessment, and tolerance may develop
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