The RSSDI Treatment Ladder, In Plain Language Step one: lifestyle change plus metformin for most newly diagnosed adults [1] Step two: if HbA1c is still above target after about three months, a second medicine is added rather than delayed Step three: the choice of that second medicine depends on your risk profile heart disease, kidney disease, or obesity push the decision towards a GLP-1 receptor agonist or an SGLT2 inhibitor [2] Step four: insulin is brought in when oral and injectable non-insulin options are not enough, and it can later be reduced if a GLP-1 drug is added Who Is Most Likely To Benefit From Adding A GLP-1
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When this begins to affect appetite or sleep, it shows that the digestive tract is struggling to regain its usual pace
This article compares how each works, what the clinical evidence shows, their side effect profiles, NHS eligibility criteria, and practical considerations helping you have an informed conversation with your GP or specialist
A lot of celebrities are on it, he says
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