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What were doing in my lab, and the others around the world, is trying to compress the period of our lives that is morbid

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This bivalent effect of aminothiols (pro-oxidant and antioxidant), confirmed for in vitro LDL oxidation (Halvorsen et al, 1996), might explain the discrepancies observed between moderate and severe hyperhomocysteinemia

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What also concerned me was evidence that elevated TMAO compromises the release of nitric oxide release in endothelial cells thereby interfering with the vasodilatory mechanism which can contribute to hypertension