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The enzyme DHODH acts as a safeguard against ferroptosis in eye tissues like the cornea and retina without relying on GPX4, but when this protective pathway is diminished, particularly when disrupted by oxidative stress, it could lead to damage of corneal and retinal cells by facilitating the progress of ferroptosis

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Although GSH, GSSG, and GSB are exported by Mrp1, as demonstrated by the strong impairment of the respective export process by inhibition or knockout of Mrp1 (Hirrlinger et al

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