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The included studies on exendin-4 exposure were all performed in mouse models ( In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )

However, there were a fair number of reports saying Thymosin Beta-4 increases the secretion of pro-inflammatory compounds

Lifestyle modifications resulting in weight loss led to an increase in HDL-C and decrease in LDL-C, triglycerides, and apoB

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10.1097/PEC.0000000000001695 65

JACC Heart Fail 2015;3:275-82