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That approval validated the core mechanism: stabilizing cardiolipin improves mitochondrial function in measurable, clinically significant ways

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In detail, elevation of HDAC6 promotes the formation of aggresome, which emerges as a cytoprotective response in the clearance of toxic misfolded protein aggregates found in neurodegenerative disease such as Parkinsons disease [90], via binding polyubiquitinated misfolded protein including CFTR-F508 [91]

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Both serve as solvents or diluents, but they have key differences

HTRF ratios were obtained by dividing the acceptor signal (665 nm) by the donor signal (620 nm)