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Heterogeneities among studies were found for most markers, and meta-regressions indicated that age and publication year may influence the meta-analysis results

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Certain uricosuric agents, including probenecid, sulfinpyrazone, benzbromarone, and losartan, exert their influence by inhibiting urate reabsorption, binding to URAT1, and promoting urate excretion [59]

SCN may act on somatostatinergic neurons and GH-releasing hormones (GHRH) to synchronize the GH rhythm with the light-dark cycle (Willoughby and Martin, 1978

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