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FitzGerald MP, Payne CK, Lukacz ES et al: Randomized multicenter clinical trial of myofascial physical therapy in women with interstitial cystitis/painful bladder syndrome and pelvic floor tenderness
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Poor sleep may compound the muscle-loss risk on GLP-1 therapy Kion Sleep here Consider a blood panel To rule out iron deficiency, B12 depletion, or vitamin D insufficiency as contributing factors A Note on Rate of Weight Loss Very rapid weight loss on GLP-1 medications (more than 11.5 pounds per week on average) significantly increases the proportion of lean mass lost
A recent study demonstrated that GLP-1 has a neurotrophic effect and promotes neurotrophic processes in the brain (Mainardi et al., 2015)
PMCID: PMC9531956
Notably, the observed improvements were present regardless of PAP therapy use, highlighting an important adjunct benefit of GLP-1RA and combined therapies to standard of care OSA treatments
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