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Medical weight loss programs are generally safe when supervised by a qualified healthcare provider

Bastian BC, LeBoit PE, Pinkel D

The physiologic adaptations to weight loss make it difficult to achieve long-term sustained weight loss with diet and exercise alone

1991;261(2 Pt 2):R501-507

Based on the trajectory, it appears that the weight loss curve was still declining at 68 weeks, though at a slower rate, suggesting a plateau would eventually be reached with continued treatment

This precision approach helps distinguish between expected metabolic adjustment symptoms and true adverse effects, optimizing both safety and efficacy