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Fatigue combined with cold intolerance and brain fog warrants measuring Free T3 rather than TSH alone. The obese trial cohorts lost roughly 8% of body weight at 1 mg in Phase 2 and about 28% at 12 mg in the 80-week Phase 3 trial

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Ali, who was also not involved in this review, noted that a problem affecting a lot of research in this area is that it comes out of smaller studies as double-blind controlled studies require a lot of time and monetary investment. Obesity is a multifactorial condition