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[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Pomatto-Watson LCD, Bodogai M, Bosompra O, Kato J, Wong S, Carpenter M, Duregon E, Chowdhury D, Krishna P, Ng S, Ragonnaud E, Salgado R, Gonzalez Ericsson P, Diaz-Ruiz A, Bernier M, Price NL, Biragyn A, Longo VD, de Cabo R

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As a result, any microparticle formulation cannot deliver molecular drug directly to the epithelial cells where initial infection takes place because of the protective mucin barrier that is produced by, and covers, these cells (41)

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This is where advanced delivery methods become important