ApoE does so many different things that trying to target it in various traditional wayslike small-molecule approaches to interfere with one of its actions, for examplehasn't really worked, says Howard Fillit, cofounder and chief science officer at ADDF
doi: 10.1155/2021/6665563
It boosts collagen, fades dark spots, and refines poresall with long-lasting results
For example, exosomes secreted by metastatic melanoma cells can instigate a pro-inflammatory gene signature in both lung fibroblasts and brain astrocytes, which promotes the formation of an inflammatory metastatic niche, suggesting that the reprogramming of stromal cells by tumor cell exosomes is a general mechanism in distant organs
Through a variety of mechanisms, including the regulation of cell behaviors like proliferation, differentiation, increased maturation and apoptosis, autophagy, and epithelial-mesenchymal transition (EMT), as well as the modulation of interactions between cells and their microenvironment, such as the suppression of inflammation, the immune system, angiogenesis, and anti-oxidants, vitamin D can control tumor cells (64)
PubMed DOI Sikiric P, Seiwerth S, Rucman R, et al
