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The three subtypes AMY1 (CTR + RAMP1), AMY2 (CTR + RAMP2), and AMY3 (CTR + RAMP3) each exhibit distinct ligand affinity profiles and tissue distribution patterns (Hay et al., Pharmacological Reviews , 2015

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However, 5 of these 11 drugs did not significantly alter the total cell number, which might suppress senescence phenotypes, whereas 5 significantly reduced both senescent cell and total cell numbers (Fig