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The optimized formulation was intranasally administered in rats with rotenone-induced PD animal model, motor function and coordination were investigated besides testing the levels of different biomarkers and histopathological examination

[41]Yuan H, Liu Q, et al

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Among those studies, half of the reports investigated only the binding to the transporter, either using competitive cellular uptake assays, or in situ brain perfusion in rodents with the corresponding transporter substrates, i.e., amino acids, glucose, etc

Feb 2020;113(2):383-391

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