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Glucagon secretion increases quickly following food intake and is directed primarily to the liver in order to stimulate hepatic glycogenolysis during meals [78]

Caron, A., Lee, S., Elmquist, J

(2003c)

GLP-1 glucagon-like peptide-1 is a hormone your gut releases naturally every time you eat

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Tryptophan metabolites, including indole-3-lactic acid from Lactobacillus species activate GPR142 on L cells and promote the differentiation of intestinal stem cells toward the L cell lineage by upregulating transcription factors Math1, Neurog3, and Neurod1 while suppressing Notch signaling, making tryptophan metabolism a long-term structural regulator of GLP-1 secretory capacity, not merely an acute trigger