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In addition, upstream modulators of ERK, such as Erbb3 , Axl , and Itga6 , were also upregulated (Fig

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Moreover, severe caloric restriction or prolonged fasting, both of which are components of the IF regimen, can affect the hypothalamic-pituitary-gonadal (HPG) axis leading to dysregulation in the release of reproductive hormones, namely estrogen and progesterone