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Patients with significant comorbidities, those taking multiple medications, or those with complex medical histories may be underrepresented in clinical trials

Click here to read the expert reaction to the BMJ article: Click here to read the BMJ article: Science Media Centre University of East London Wegovy(semaglutide) HCP Mounjaro (tirzepatide) HCP To view or add a comment, sign in Despite substantial weight loss, most obesity drugs such as Wegovy and Mounjaro do not meaningfully improve quality of life and few show cardiovascular benefits at one year, finds a new study in The BMJ Greater weight loss was consistently accompanied by higher rates of side effects and treatment discontinuation, which the authors say indicates a clear benefit-harm trade-off