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Graphical Abstract 1 Introduction Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory lesions of joint tissues, which display pain, swelling, and decreased function of the affected joints in clinical (Khanna et al., 2021)

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According to the FDA prescribing information, the most commonly reported adverse reactions in clinical trials were predominantly gastrointestinal in nature

The NHS and British Dietetic Association provide resources on implementing the 5:2 approach safely