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A large-scale genome-wide association study published in Nature in April 2026, conducted by 23andMe researchers using data from 27,885 GLP-1 medication users, identified a specific variant in the GLP1R gene the gene that encodes the primary receptor these drugs target associated with differential weight loss efficacy
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This may cause a decrease in fatty tissues particularly in resistant fatty areas such as the belly region
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Individuals suffering from malabsorption may find this particularly beneficial
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