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c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1

The progressive degeneration of neuronal cells that accompanies the decline of memory and other cognitive functions in subjects with Alzheimers disease is associated with an intracellular aggregation of Tau fibrils, an extra-neuronal accumulation of b-amyloid peptides into senile plaques, and an oxidation-reduction (redox) imbalance of complex etiology

It is important to note that in nucleated cells, Bcl-XL inhibits caspase-8 with consequent switch of the cell death pathway towards necroptosis [261]