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How peptide therapy powered Audrey's remarkable results

The dog CluGST A3-3 protein, differing in only four of the residues forming the substrate-binding site in HsaGST A3-3 and EcaGST A3-3, displays a specific activity with 5-AD of only 1.1 mol min 1 mg 1 , 200-fold lower than the specific activities of the human and equine enzymes (A

On the basis of this finding the authors suggested the pathway shown in Figure 3A, according to which glucose-derived -ketoglutarate leaves the astrocytic TCA cycle in exchange with malate, generated via oxaloacetate (OAA), which in turn had been formed from aspartate in a transamination process

doi:10.1007/s00125-020-05196-3 34

GSH is enzymatically converted to its oxidized form, glutathione disulfide (GSSG)

BMI, waist circumference, and waist-to-height ratio improved significantly with combination therapy