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With over 50 million individuals currently affected by dementia worldwidea number projected to double by 2050there is a critical need for novel, mechanism-based interventions, particularly in the absence of curative therapies (Sexton et al., 2022)

Tukey, Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice

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In fact, HTyr was shown to prevent oxidative stress-induced mitochondrial dysfunction and osteoblast apoptosis by decreasing the cleavage of optic atrophy 1 (OPA1), one of the most important mitochondrial dynamics proteins, and by activating the Akt/glycogen synthase kinase 3 (GSK3) signaling pathway