Intensity of behavioral disturbances and seizure presentation assessment After paracetamol application, intensity of progressing behavioral disturbances and seizure presentation was continuously monitored, and assessed and scored (score 0 - normal, score 1 - rearing on hind legs, shaking, 2 - sleepy, tottering walk, 3 - sleepy, tottering walk and repeatedly falling down, 4 - sleepy, tottering walk and repeatedly falling down, jerking of the extremities, 5 - lying down, generalized convulsions) at particular time points depending on the regimen used, as described before
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The majority (90%) of the APAP is funneled into phase II metabolic pathways, in which APAP conjugation is catalyzed by UDP-glucuronosyl transferases (UGT) and sulfotransferase (SULT), with conversion to glucouronidated and sulfated metabolites that are eliminated from the body in the urine 8 (Figure 1)
1 The initiation, also called priming, corresponds to the activation of the immediate-early response genes by pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF ) 2 and interleulin-6 (IL-6) 3 that induces the G0/G1 transition of quiescent hepatocytes
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Learn the start-low protocol, dosing ladder, and mistakes to skip
