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The force field OPLS4 was used and all the other options were set to default values

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10.1016/0024-3205(86)90540-0 Hoshi T, Heinemann S: Regulation of cell function by methionine oxidation and reduction

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This makes it a preferred solvent for peptide reconstitution, solution preparation, and experimental consistency in controlled research environments

It has an essential role in the transport of long-chain fatty acids to the mitochondrial matrix for oxidation, which is why it is of fundamental importance in energy production