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A practical approach used in clinical trials for GLP-1 class-switches involves a two-week washout or, if the patient is medically stable, direct substitution starting at the lowest retatrutide titration dose (2 mg weekly in the phase 2 protocol) with dose escalation over 24 weeks [2]

[4] [10] Starting with lower doses and gradual titration helps minimise these effects

Flushing is preserved on the contralateral side, leading to asymmetric physiologic flushing (harlequin syndrome)

Thats 890 million adults 18 and older, and 160 million children and adolescents ages 5 to 19

A: Poviztra Semaglutide may start to lower blood sugar levels within the first week of treatment, but it can take several weeks to see the full effects

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