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These are not head-to-head trials the populations and designs differ and retatrutide carried higher GI side-effect and discontinuation rates

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Available from: Winston AW, Rinehart RS, Riley GP, Vacchiano CA, Pellegrini JE

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However, product quality varies widely and no regulatory oversight ensures what you receive matches what the label claims

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The higher rates in the diabetes population likely reflect the baseline GI motility alterations common in type 2 diabetes (diabetic gastroparesis, autonomic neuropathy) and the potential for additive GI effects with concomitant metformin use

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