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The most promising compound in the ARI family is epalrestat [117]

Advantage : Neither (tie) Weight Loss Efficacy# Ribupatide : Injectable Phase 2 in China showed 23.6% weight loss at 8 mg at 36 weeks (21.8% placebo-adjusted), with no plateau

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Hypertension Programmed by Perinatal High-Fat Diet: Effect of Maternal Gut Microbiota-Targeted Therapy

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Furthermore, the option to continue or initiate new AD medication during the trial, including the amyloid lowering monoclonal antibodies, was not a randomization stratification factor and may therefore act as a confounding factor if their use across treatment arms is unequal