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The dosing protocols circulating online are extrapolations from preclinical work

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D., Leone, L., Pedata, M., Meli, R., & Calignano, A

Another commenter recommended CMS establish an option for ACO participants to file a MIPS EUC Exception application for the quality performance category at the NPI or TIN level, citing how if approved, this would remove the requirement for the ACO to report 100% of eligible patients from those EUC-approved providers, while still allowing the ACO to submit and report data for all other participants

Loading Phase (Weeks 1-4): 2 to 2.5 mg twice weekly (Monday/Thursday schedule) Maintenance Phase (Weeks 5+): 2 mg once every 7 to 14 days Administration: Subcutaneous injection, location flexible due to systemic distribution Total Cycle: 8 to 12 weeks with 4 to 8 weeks off between cycles The convenience of twice-weekly dosing during loading and weekly or biweekly dosing during maintenance fits easily into Retatrutide schedules

If you know your levels are low, B12 supplements are a great start, but you're going to be playing catch-up, so dont expect things to be back to normal immediately