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Exogenous pigmentations are usually associated with traumatic or iatrogenic events resulting in the deposition of foreign material directly into the mucosal tissues (Table 52)

Notably, Laurent et al.(51) recently demonstrated that liver-targeted recombinant AAV8 (rAAV8) gene therapy effectively rescued LAL-D in a Lipa/ mouse model, correcting lipid accumulation and normalizing gene expression patterns and mitochondrial function, suggesting rAAV8-mediated liver gene transfer may be an effective curative approach

a high content of ascorbic acid could provide possible protection of folate from degradation 404

Teriflunomide may be an attractive anti-tumor medicine due to its efficacy at lower doses compared to other medications that inhibit DNA synthesis, such as methotrexate, and may thus avoid cumulative cytotoxic damage to the body (129)