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Males were dosed for 4 weeks prior to mating, and females were dosed for 2 weeks prior to mating and throughout organogenesis until Gestation Day 17

From a safety perspective, the FDA and pharmaceutical manufacturers establish expiration dates based on stability testing to ensure medication quality and effectiveness

For mild cases or other GI conditions, starting at even lower doses (0.125 mg weekly via precise syringe measurement from a 2.5mg/mL vial) and titrating over eight to twelve weeks per level can improve tolerability

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And although caffeine consumed in moderation may not be dehydrating, too much coffee can be

Seek prompt medical evaluation if you experience any of the following: Difficulty swallowing, meaning food catching in the throat or chest