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Dehydration forces kidneys to work harder to filter waste, raising the risk of acute kidney injury, kidney stones, and chronic kidney disease

Third, topiramate inhibits excitatory transmission by antagonizing some types of glutamate receptors

doi: 10.3389/fendo.2020.00178 24 DrivaSKorkontzelouATonstadSTentolourisNKatsaounouP

GLP-1 Drugs Already Slow Digestion Alcohol Compounds This GLP-1 medications: slow gastric emptying reduce appetite lower blood sugar blunt hunger signals Alcohol: is absorbed partly in stomach absorbed faster when digestion is altered affects liver glucose regulation What this means: When someone drinks wine on GLP-1s: Alcohol hits harder Intoxication may occur faster Blood sugar can drop more unpredictably Nausea risk increases This is why many GLP-1 users report: One glass feels like three dizziness nausea flushing fatigue 2

Tsukamoto M, Niimi N, Sango K, Takaku S, Kanazawa Y, Utsunomiya K

These activities are consistent with our demonstration that the peptide increases ATP generation and cAMP production in a sAC-dependent manner