Start your intake What Does GLP-1 Non-Response Actually Mean GLP-1 non-response occurs when a patient follows a consistent semaglutide protocol but loses less than 5% of their starting body weight after 12 weeks or experiences weight loss plateau before reaching therapeutic goals
Clinically meaningful response usually begins at 1.0 mg or higher
Its usually dose, titration speed, expectation mismatch, an unrecognized plateau, or care that isnt built for obesity medicine
Although I took Wegovy for my weight loss, the same problems I describe here exist for all of the new drugs in this category (Wegovy, Saxenda, Mounjaro, semaglutide, liraglutide, tirzepatide, and others) because they are all very similar drugs that work in very similar ways
13.7% for semaglutide over 72 weeks
Muscle loss lowers your resting metabolism, which can slow further weight loss