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Although the carboxylate group of the E residue of GSH makes no direct contacts with the I site, other portions of the residue contact D150 (protomer B) and, indirectly, R227 (protomer A) at the inter-protomer interface (Figs

[Google Scholar] 188.Meng J.-M., Cao S.-Y., Wei X.-L., Gan R.-Y., Wang Y.-F., Cai S.-X., Xu X.-Y., Zhang P.-Z., Li H.-B

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Neuropathology of AD involves the accumulation of senile plaques (protein fragments of amyloid-, A) and neurofibrillary tangles (NTFs, deposits of phosphorylated protein tau) in the brain

doi:10.1038/s41522-025-00701-1 81

The release of cytochrome c activates, leading to the subsequent activation of downstream effector caspases, primarily caspase-3