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DOI: Received: Accepted: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-19369-9 Online ISBN: 978-3-031-19369-9 eBook Packages: Living Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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Increased release of glutamate from presynaptic terminals activates N -methyl-D-aspartate (NMDA) receptors on postsynaptic terminals to lead to a widespread neuronal depolarization or spreading depression, further disrupting the sodium ion, potassium ion, and calcium ion equilibria (Langlois et al., 2006)

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