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NHEKs (2 10 5 cells/well) were co-transfected with a STAT3-responsive reporter and CAV-1 RNAi or control RNAi

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It is possible that the latter group might find a reduction in the efficacy of their HRT when using tirzepatide (for the same pharmacokinetic reasons discussed regarding contraception), but the likelihood and magnitude of this is unknown

Repine JE, Bast A, Lankhorst I