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Integration of GLP-1RA or SGLT2i in Patients With T2D With or at Risk of atherosclerotic CVD PICO 4: In patients with T2D and either atherosclerotic CVD (ASCVD) or high CV risk, what is the role of novel anti-hyperglycemic agents compared with placebo for reduction of a composite of CV death, nonfatal MI, or nonfatal stroke

GLP-1RAs inhibit gastric emptying by acting on receptors located in the gastrointestinal tract

Symptoms include localised injection site redness and swelling, or systemic signs such as widespread hives, facial swelling, breathing difficulty, or cardiovascular collapse

Across multiple trials and medicines

Johns EJ, Kopp UC, DiBona GF

Nausea typically improves within 8 to 12 weeks at a given dose, but constipation rates remain relatively stable across the treatment period because the medication continues to slow gut motility for as long as you take it