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Methods: A retrospective analysis of the OPTIMISE registry was conducted, focusing on adult patients with anterior circulation AIS treated with EVT between January 2018 and December 2021

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The pKa, which describes the dissociation of the neutral form to the negatively charged form, of sulfadiazine is 6.5 17 , making the dissociation of sulfadiazine relevant in the environment, where even slight pH changes in the vicinity of the pKa will have a major impact on the balance between the neutral and ionized fractions (Fig

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