Indeed, we found male L-DKO mice to have a greater hepatocellular injury than female Gclc L-KO mice (Fig
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The model is available in PEtab format 50 at All model analyses, parameter estimation and identifiability analysis have been carried out using the dMod 51 package for R
3, Supplementary Figs
After 56 weeks: Placebo group lost 1.6% of body weight Starting dose (3.75/23 mg) group lost 5.1% of body weight Top dose (15/92 mg) group lost 10.9% of body weight Beyond weight loss, the CONQUER trial showed significant improvements in blood pressure, waist circumference, lipid profiles, glycemic parameters, and inflammatory biomarkers compared to placebo