CYC is a prodrug that undergoes hepatic conversion to its active metabolite, 4-hydroxycyclophosphamide (4-OH-CPA), primarily facilitated by cytochrome P450 (CYP) enzymes, including CYP2B6, CYP2C9, and CYP3A4, with additional contributions from CYP2A6, CYP2C8, and CYP2C19 (Lamba et al., 2014)
Erratum in: Am Fam Physician 2001;64(4):570
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Potential interaction with medications: e.g., in cancer patients glutathione may theoretically reduce efficacy of certain chemotherapy by protecting cancer cells from oxidative damage
Increasing evidence suggests that microbial infection may also contribute to RA development, with Porphyromonas gingivalis , Proteus mirabilis , and Mycobacteria among the bacterial species with potential aetiological roles (Li et al
