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JAMA Network Open 8 , e2457349e2457349 (2025)

Public Health 9:559595

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GLP-1 and GIP receptors are expressed in regions including the hypothalamus, hindbrain, and area postrema, and tirzepatide is used as a tool compound to probe how dual receptor engagement modulates neuronal firing, appetite-related gene expression, and neuroinflammation markers in cell and organoid systems

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