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doi: 10.1016/0006-2952(66)90197-3

HEDISON DR

Comparative Mechanisms with Other Agents Compared with metformin, which improves insulin sensitivity primarily through hepatic and muscular pathways, GLP-1 RAs act centrally and peripherally to influence appetite, glucose metabolism, and systemic inflammation

e-mail: [email protected] Recibido para publicacin julio 12, 2005 Aceptado para publicacin enero 4, 2007 SUMMARY Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis

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