However, in a study on the potential toxic effects of topiramate on the liver and kidney of male mice, topiramate significantly decreased the activities of the antioxidant enzymes SOD and CAT, while increasing MDA and NO levels (El Makawy et al., 2022)
Likewise, concurrent use of certain medicationsparticularly fluoxetine (OR = 5.236)substantially increases serious adverse event risk
NO is a potent vasodilator, and low levels of intracellular ROS play a crucial role in normal redox signaling that helps to maintain vascular function and integrity under physiological conditions (122)
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Phase 2 trial data published in The New England Journal of Medicine (2023) reported up to approximately 24% total body weight reduction over 48 weeks in a dose-dependent manner
It is intended as a raw material for scientific research and experimental development
